Photosensitivity from Nalidixic Acid

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Nalidixic acid: an antibacterial paradox.

Nalidixic acid was found to be most bactericidal against various species of gram-negative bacteria at 50 to 200 mug/ml. With all species tested, increases in the concentration of nalidixic acid above this range reduced, rather than increased, its bactericidal effect so that, at levels in the region of 400 mug/ml, the drug was relatively bacteriostatic. Therefore, the mode of action of nalidixic...

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Antibacterial activity of methyl gallate isolated from Galla Rhois or carvacrol combined with nalidixic acid against nalidixic acid resistant bacteria.

Methyl gallate is a major component of Galla Rhois, as carvacrol is of oregano essential oils. Both have shown good antibacterial activity against intestinal bacteria. This study investigated the antibacterial activities of nalidixic acid in combination with methyl gallate and carvacrol against nalidixic acid resistant bacteria. The combined effect of nalidixic acid with methyl gallate and carv...

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Convulsions and hyperglycaemia associated with nalidixic acid.

Hyperglycaemia and convulsions in patients taking nalidixic acid are usually associated with overdosage of the drug or an underlying epileptic tendency.' :1 Nalidixic acid may also interfere with biochemical determinations of plasma and urinary glucose, giving falsepositive results. We describe an otherwise healthy patient who had convulsions and hyperglycaemia (confirmed by a glucose-specific ...

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Acute intracranial hypertension after nalidixic acid administration.

Nalidixic acid (Negram) is an antimicrobial agent widely used in the treatment of urinary tract infection. Some years ago Boreus and Sundstrom (1967) reported intracranial hypertension in a 6-month-old boy treated with nalidixic acid at the manufacturer's recommended dose. Only a few cases have been reported since, mostly in children treated either with large doses (Fisher, 1967) or for prolong...

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ژورنال

عنوان ژورنال: Proceedings of the Royal Society of Medicine

سال: 1973

ISSN: 0035-9157

DOI: 10.1177/003591577306600805